s pneumoniae atcc 10813 Search Results


efficacy against s pneumoniae atcc 10813  (ATCC)
94
ATCC efficacy against s pneumoniae atcc 10813
In vivo PAE of garenoxacin after administration of single doses of 16 and 64 mg/kg against S. pneumoniae ATCC 10813, S. aureus ATCC 6538p, and K. pneumoniae ATCC 43816. Each symbol represents the mean ± standard deviation for two mice. The widths of hollow bars represent the duration of time total serum levels exceeded the MIC for the infecting pathogen. The widths of the solid bars represent the duration of time free drug serum levels exceeded the MIC for the infecting pathogen.
Efficacy Against S Pneumoniae Atcc 10813, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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atcc 10813 gar  (ATCC)
94
ATCC atcc 10813 gar
In vivo PAE of garenoxacin after administration of single doses of 16 and 64 mg/kg against S. pneumoniae ATCC 10813, S. aureus ATCC 6538p, and K. pneumoniae ATCC 43816. Each symbol represents the mean ± standard deviation for two mice. The widths of hollow bars represent the duration of time total serum levels exceeded the MIC for the infecting pathogen. The widths of the solid bars represent the duration of time free drug serum levels exceeded the MIC for the infecting pathogen.
Atcc 10813 Gar, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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escherichia coli 9377  (DSMZ)
96
DSMZ escherichia coli 9377
In vivo PAE of garenoxacin after administration of single doses of 16 and 64 mg/kg against S. pneumoniae ATCC 10813, S. aureus ATCC 6538p, and K. pneumoniae ATCC 43816. Each symbol represents the mean ± standard deviation for two mice. The widths of hollow bars represent the duration of time total serum levels exceeded the MIC for the infecting pathogen. The widths of the solid bars represent the duration of time free drug serum levels exceeded the MIC for the infecting pathogen.
Escherichia Coli 9377, supplied by DSMZ, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pssp cdc  (ATCC)
94
ATCC pssp cdc
Study organisms and MICs of MX-2401 and penicillin
Pssp Cdc, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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strain atcc 10813  (ATCC)
97
ATCC strain atcc 10813
Study organisms and MICs of MX-2401 and penicillin
Strain Atcc 10813, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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47 20 s aureus atcc  (ATCC)
99
ATCC 47 20 s aureus atcc
Study organisms and MICs of MX-2401 and penicillin
47 20 S Aureus Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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organisms  (ATCC)
99
ATCC organisms
Study organisms and MICs of MX-2401 and penicillin
Organisms, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s pneumoniae cdc  (ATCC)
85
ATCC s pneumoniae cdc
In vivo PAE of daptomycin against S. <t>pneumoniae</t> ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.
S Pneumoniae Cdc, supplied by ATCC, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s pneumoniae atcc 10813  (ATCC)
99
ATCC s pneumoniae atcc 10813
In vivo PAE of daptomycin against S. <t>pneumoniae</t> ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.
S Pneumoniae Atcc 10813, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pd indices  (ATCC)
99
ATCC pd indices
In vivo PAE of daptomycin against S. <t>pneumoniae</t> ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.
Pd Indices, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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glucophagetm  (Bristol Myers)
90
Bristol Myers glucophagetm
In vivo PAE of daptomycin against S. <t>pneumoniae</t> ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.
Glucophagetm, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


In vivo PAE of garenoxacin after administration of single doses of 16 and 64 mg/kg against S. pneumoniae ATCC 10813, S. aureus ATCC 6538p, and K. pneumoniae ATCC 43816. Each symbol represents the mean ± standard deviation for two mice. The widths of hollow bars represent the duration of time total serum levels exceeded the MIC for the infecting pathogen. The widths of the solid bars represent the duration of time free drug serum levels exceeded the MIC for the infecting pathogen.

Journal:

Article Title: Pharmacodynamics of the New Des-F(6)-Quinolone Garenoxacin in a Murine Thigh Infection Model

doi: 10.1128/AAC.47.12.3935-3941.2003

Figure Lengend Snippet: In vivo PAE of garenoxacin after administration of single doses of 16 and 64 mg/kg against S. pneumoniae ATCC 10813, S. aureus ATCC 6538p, and K. pneumoniae ATCC 43816. Each symbol represents the mean ± standard deviation for two mice. The widths of hollow bars represent the duration of time total serum levels exceeded the MIC for the infecting pathogen. The widths of the solid bars represent the duration of time free drug serum levels exceeded the MIC for the infecting pathogen.

Article Snippet: These analyses suggest that treatment efficacy was dependent upon dose level and independent of the dosing intervals studied. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 3. caption a7 (a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. table ft1 table-wrap mode="anchored" t5 TABLE 2. caption a7 Dosing interval ED 25 (95% CI) a ED 50 (95% CI) ED 75 (95% CI) Static dose (95% CI) 1 log kill (95% CI) S. pneumoniae q3h 11.5 (8.2-14.8) 23 (16.3-29.7) 46.2 (32.8-59.6) 18.2 (12.9-23.5) 25.8 (18.3-33.3) q6h 8.3 (3.7-12.8) 18.4 (8.2-28.6) 41.1 (18.5-63.7) 16 (7.2-24.8) 25 (11.2-38.8) q12h 14.4 (0.6-28.2) 31 (0.7-61.3) 64 (3-125) 31 (0.7-61.3) 50.3 (23.3-78.3) q24h 12.9 (1.0-24.9) 38.8 (1.2-76.4) 115 (111-227) 65.7 (1.7-130) >128 S. aureus q3h 2.85 (2.6-3.1) 3.40 (3.1-3.8) 4.96 (4.5-5.5) 4.33 (3.9-4.8) 5.84 (5.3-6.4) q6h 1.05 (1.0-1.2) 4.07 (2.9-5.2) 15.9 (11.1-20.5) 10.0 (7.0-13.0) 30 (21.1-38.1) q12h 1.56 (1.4-1.8) 3.44 (3.0-3.8) 7.60 (6.7-8.5) 5.95 (5.0-7.0) 11.5 (10.1-12.9) q24h 2.9 (1.5-4.3) 7.46 (3.8-11.1) 19.1 (9.7-28.5) 7.91 (4.0-11.8) 26.6 (13.6-39.6) Open in a separate window a CI, confidence interval.

Techniques: In Vivo, Standard Deviation

(a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs.

Journal:

Article Title: Pharmacodynamics of the New Des-F(6)-Quinolone Garenoxacin in a Murine Thigh Infection Model

doi: 10.1128/AAC.47.12.3935-3941.2003

Figure Lengend Snippet: (a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs.

Article Snippet: These analyses suggest that treatment efficacy was dependent upon dose level and independent of the dosing intervals studied. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 3. caption a7 (a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. table ft1 table-wrap mode="anchored" t5 TABLE 2. caption a7 Dosing interval ED 25 (95% CI) a ED 50 (95% CI) ED 75 (95% CI) Static dose (95% CI) 1 log kill (95% CI) S. pneumoniae q3h 11.5 (8.2-14.8) 23 (16.3-29.7) 46.2 (32.8-59.6) 18.2 (12.9-23.5) 25.8 (18.3-33.3) q6h 8.3 (3.7-12.8) 18.4 (8.2-28.6) 41.1 (18.5-63.7) 16 (7.2-24.8) 25 (11.2-38.8) q12h 14.4 (0.6-28.2) 31 (0.7-61.3) 64 (3-125) 31 (0.7-61.3) 50.3 (23.3-78.3) q24h 12.9 (1.0-24.9) 38.8 (1.2-76.4) 115 (111-227) 65.7 (1.7-130) >128 S. aureus q3h 2.85 (2.6-3.1) 3.40 (3.1-3.8) 4.96 (4.5-5.5) 4.33 (3.9-4.8) 5.84 (5.3-6.4) q6h 1.05 (1.0-1.2) 4.07 (2.9-5.2) 15.9 (11.1-20.5) 10.0 (7.0-13.0) 30 (21.1-38.1) q12h 1.56 (1.4-1.8) 3.44 (3.0-3.8) 7.60 (6.7-8.5) 5.95 (5.0-7.0) 11.5 (10.1-12.9) q24h 2.9 (1.5-4.3) 7.46 (3.8-11.1) 19.1 (9.7-28.5) 7.91 (4.0-11.8) 26.6 (13.6-39.6) Open in a separate window a CI, confidence interval.

Techniques: Infection

The relationships of the garenoxacin free drug 24-h AUC/MIC ratio, the percentage of the dosing interval that levels in serum remained above the MIC, and the peak/MIC ratio for S. pneumoniae ATCC 10813 with the log10 CFU/thigh after 24 h of therapy. Each symbol represents the mean data per mouse from two thighs. R2, coefficient of determination.

Journal:

Article Title: Pharmacodynamics of the New Des-F(6)-Quinolone Garenoxacin in a Murine Thigh Infection Model

doi: 10.1128/AAC.47.12.3935-3941.2003

Figure Lengend Snippet: The relationships of the garenoxacin free drug 24-h AUC/MIC ratio, the percentage of the dosing interval that levels in serum remained above the MIC, and the peak/MIC ratio for S. pneumoniae ATCC 10813 with the log10 CFU/thigh after 24 h of therapy. Each symbol represents the mean data per mouse from two thighs. R2, coefficient of determination.

Article Snippet: These analyses suggest that treatment efficacy was dependent upon dose level and independent of the dosing intervals studied. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 3. caption a7 (a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. table ft1 table-wrap mode="anchored" t5 TABLE 2. caption a7 Dosing interval ED 25 (95% CI) a ED 50 (95% CI) ED 75 (95% CI) Static dose (95% CI) 1 log kill (95% CI) S. pneumoniae q3h 11.5 (8.2-14.8) 23 (16.3-29.7) 46.2 (32.8-59.6) 18.2 (12.9-23.5) 25.8 (18.3-33.3) q6h 8.3 (3.7-12.8) 18.4 (8.2-28.6) 41.1 (18.5-63.7) 16 (7.2-24.8) 25 (11.2-38.8) q12h 14.4 (0.6-28.2) 31 (0.7-61.3) 64 (3-125) 31 (0.7-61.3) 50.3 (23.3-78.3) q24h 12.9 (1.0-24.9) 38.8 (1.2-76.4) 115 (111-227) 65.7 (1.7-130) >128 S. aureus q3h 2.85 (2.6-3.1) 3.40 (3.1-3.8) 4.96 (4.5-5.5) 4.33 (3.9-4.8) 5.84 (5.3-6.4) q6h 1.05 (1.0-1.2) 4.07 (2.9-5.2) 15.9 (11.1-20.5) 10.0 (7.0-13.0) 30 (21.1-38.1) q12h 1.56 (1.4-1.8) 3.44 (3.0-3.8) 7.60 (6.7-8.5) 5.95 (5.0-7.0) 11.5 (10.1-12.9) q24h 2.9 (1.5-4.3) 7.46 (3.8-11.1) 19.1 (9.7-28.5) 7.91 (4.0-11.8) 26.6 (13.6-39.6) Open in a separate window a CI, confidence interval.

Techniques:

Study organisms and MICs of MX-2401 and penicillin

Journal: Antimicrobial Agents and Chemotherapy

Article Title: In Vivo Pharmacodynamics of New Lipopeptide MX-2401 ▿

doi: 10.1128/AAC.00238-10

Figure Lengend Snippet: Study organisms and MICs of MX-2401 and penicillin

Article Snippet: Study organism MIC (μg/ml) MX-2401 Penicillin a S. aureus ATCC 29213 2.0 0.5 (MSSA) ATCC 33591 2.0 R (MRSA) ATCC 6538P 1.0 0.12 (MSSA) UW 31005 2.0 R (MSSA) UW 307109 2.0 R (MRSA) S. pneumoniae ATCC 10813 0.25 0.008 (PSSP) CDC 1020 0.5 2.0 (PRSP) CDC 1199 0.25 1.0 (PRSP) CDC 1329 0.25 2.0 (PRSP) CDC 146 0.5 4.0 (PSRP) Open in a separate window a PSSP, penicillin-susceptible S. pneumoniae ; PRSP, penicillin-resistant S. pneumoniae .

Techniques:

In vivo PAE of daptomycin against S. pneumoniae ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAE of daptomycin against S. pneumoniae ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo, Concentration Assay

In vivo PAEs of free and total daptomycin concentrations of against S. aureus and S. pneumoniae

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAEs of free and total daptomycin concentrations of against S. aureus and S. pneumoniae

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo

Static doses of daptomycin for different dosing intervals

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Static doses of daptomycin for different dosing intervals

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Dose-response curves for daptomycin against various strains of S. pneumoniae.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Dose-response curves for daptomycin against various strains of S. pneumoniae.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log 10 CFU per thigh over 24 h

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log 10 CFU per thigh over 24 h

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

AUC over 24 h for free daptomycin associated with the static dose and doses producing killing of 1 and 2 log10 CFU/thigh for multiple strains of S. pneumoniae and S. aureus.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: AUC over 24 h for free daptomycin associated with the static dose and doses producing killing of 1 and 2 log10 CFU/thigh for multiple strains of S. pneumoniae and S. aureus.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: